NON-SMALL CELL LUNG CANCER (NSCLC), EGFR DOWNSTREAM PATHWAY ACTIVATION AND TKI TARGETED THERAPIES SENSITIVITY: EFFECT OF THE PLASMA MEMBRANE-ASSOCIATED NEU3.

Adenocarcinoma of Non-Small Cell Lung Cancer (NSCLC) is a severe disease.Patients carrying EGFR mutations may benefit from EGFR targeted therapies (e.g.: gefitinib).Recently, it has been shown that sialidase NEU3 directly interacts and regulates EGFR.In this work, we investigate the effect of sialidase NEU3 overexpression on EGFR pathways activatio

Claire Cartwright,1 Kerry Gibson,1 John Read,2 Ondria Cowan,1 Tamsin Dehar1  1School of Psychology, University of Auckland, New Zealand; 2Psychology Department, University of East London, Stratford Campus, Timber Connectors London, UK Abstract: Long-term antidepressant treatment has increased and there is evidence of adverse effects; however,

Intraspecific temporal differentiation and population structure should be accounted in fishery, artificial breeding and introduction of anadromous species to provide stability of their ecological and genetic Mustard structure and maintain their high abundance.There is shown for the case of pacific MAGNESIUM ORANGE salmons that ignoring of the popul

This study aimed to examine the relationships between perceived internal and external salary equity and affective commitment, as well as the moderation effect of gender on these relationships among university academic staff in Egypt.Structural equation modeling was used to test the study hypotheses, based on data obtained through a face-to-face que